The hypothalamic-spinal dopaminergic system: a target for pain modulation
نویسندگان
چکیده
منابع مشابه
Hypothalamic modulation of the midbrain dopaminergic system
Ventral tegmental area (VTA) dopaminergic (DAergic) and GABAergic neurons are critically involved in mechanisms of reward, reinforcement and emotional arousal. The hypothalamus regulates the homeostatic drive to eat and sends a massive output to the VTA, including projections from neurons containing orexins, the novel neuropeptides, which potently modulate arousal and feeding. Single-unit extra...
متن کاملRapid Dopaminergic Modulation of the Fish Hypothalamic Transcriptome and Proteome
BACKGROUND Dopamine (DA) is a major neurotransmitter playing an important role in the regulation of vertebrate reproduction. We developed a novel method for the comparison of transcriptomic and proteomic data obtained from in vivo experiments designed to study the neuroendocrine actions of DA. METHODS AND FINDINGS Female goldfish were injected (i.p.) with DA agonists (D1-specific; SKF 38393, ...
متن کاملDopaminergic modulation of spinal neuronal excitability.
It is well recognized that dopamine (DA) can modulate spinal networks and reflexes. DA fibers and receptors are present in the spinal cord, and evidence for DA release within the spinal cord has been published. A critical gap is the lack of data regarding dopaminergic modulation of intrinsic and synaptic properties of motoneurons and ventral interneurons in the mammalian spinal cord. In this pa...
متن کاملTitle: Dopaminergic Modulation of Locomotor Network Activity in the Neonatal Mouse Spinal Running Title: Dopaminergic Modulation of Locomotion Introduction
19 20 Dopamine is now well established as a modulator of locomotor rhythms in a variety of 21 developing and adult vertebrates. However, in mice while all five dopamine receptor subtypes 22 are present in the spinal cord it is unclear which receptor-subtypes modulate the rhythm. 23 Dopamine receptors can be grouped into two families – the D 1/5 receptor group and the D 2/3/4 24 group that have ...
متن کاملDopaminergic modulation of spinal neurons and synaptic potentials in the lamprey spinal cord.
It has been shown previously that dopamine-immunoreactive cells and processes are present in the lamprey spinal cord and that dopamine modulates the cycle period of fictive swimming. The present study was undertaken to further characterize the effects of dopamine on the cellular properties of lamprey spinal neurons and on inhibitory and excitatory postsynaptic potentials to determine how dopami...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2019
ISSN: 1673-5374
DOI: 10.4103/1673-5374.250567